diff --git a/src/types/list.rs b/src/types/list.rs
index 14e9f63b68d..a54510e62ca 100644
--- a/src/types/list.rs
+++ b/src/types/list.rs
@@ -83,17 +83,34 @@ impl PyList {
         }
     }
 
+    /// Takes the slice `self[low:high]` and returns it as a new list.
+    ///
+    /// Out-of-range indices are clipped to `self.len()`.
+    pub fn slice(&self, low: usize, high: usize) -> &PyList {
+        unsafe {
+            self.py().from_owned_ptr(ffi::PyList_GetSlice(
+                self.as_ptr(),
+                low as Py_ssize_t,
+                high as Py_ssize_t,
+            ))
+        }
+    }
+
     /// Sets the item at the specified index.
     ///
-    /// Panics if the index is out of range.
-    pub fn set_item<I>(&self, index: isize, item: I) -> PyResult<()>
+    /// Raises `IndexError` if the index is out of range.
+    pub fn set_item<I>(&self, index: usize, item: I) -> PyResult<()>
     where
         I: ToPyObject,
     {
         unsafe {
             err::error_on_minusone(
                 self.py(),
-                ffi::PyList_SetItem(self.as_ptr(), index, item.to_object(self.py()).into_ptr()),
+                ffi::PyList_SetItem(
+                    self.as_ptr(),
+                    index as Py_ssize_t,
+                    item.to_object(self.py()).into_ptr(),
+                ),
             )
         }
     }
@@ -110,13 +127,16 @@ impl PyList {
 
     /// Inserts an item at the specified index.
     ///
-    /// Panics if the index is out of range.
-    pub fn insert<I>(&self, index: isize, item: I) -> PyResult<()>
+    /// If `index >= self.len()`, inserts at the end.
+    pub fn insert<I>(&self, index: usize, item: I) -> PyResult<()>
     where
         I: ToBorrowedObject,
     {
         item.with_borrowed_ptr(self.py(), |item| unsafe {
-            err::error_on_minusone(self.py(), ffi::PyList_Insert(self.as_ptr(), index, item))
+            err::error_on_minusone(
+                self.py(),
+                ffi::PyList_Insert(self.as_ptr(), index as Py_ssize_t, item),
+            )
         })
     }
 
@@ -251,14 +271,27 @@ mod tests {
         });
     }
 
+    #[test]
+    fn test_slice() {
+        Python::with_gil(|py| {
+            let list = PyList::new(py, &[2, 3, 5, 7]);
+            let slice = list.slice(1, 3);
+            assert_eq!(2, slice.len());
+            let slice = list.slice(1, 7);
+            assert_eq!(3, slice.len());
+        });
+    }
+
     #[test]
     fn test_set_item() {
         Python::with_gil(|py| {
             let list = PyList::new(py, &[2, 3, 5, 7]);
             let val = 42i32.to_object(py);
+            let val2 = 42i32.to_object(py);
             assert_eq!(2, list.get_item(0).extract::<i32>().unwrap());
             list.set_item(0, val).unwrap();
             assert_eq!(42, list.get_item(0).extract::<i32>().unwrap());
+            assert!(list.set_item(10, val2).is_err());
         });
     }
 
@@ -285,12 +318,15 @@ mod tests {
         Python::with_gil(|py| {
             let list = PyList::new(py, &[2, 3, 5, 7]);
             let val = 42i32.to_object(py);
+            let val2 = 43i32.to_object(py);
             assert_eq!(4, list.len());
             assert_eq!(2, list.get_item(0).extract::<i32>().unwrap());
             list.insert(0, val).unwrap();
-            assert_eq!(5, list.len());
+            list.insert(1000, val2).unwrap();
+            assert_eq!(6, list.len());
             assert_eq!(42, list.get_item(0).extract::<i32>().unwrap());
             assert_eq!(2, list.get_item(1).extract::<i32>().unwrap());
+            assert_eq!(43, list.get_item(5).extract::<i32>().unwrap());
         });
     }
 
diff --git a/src/types/tuple.rs b/src/types/tuple.rs
index b34422b93d9..b8b49fbd87d 100644
--- a/src/types/tuple.rs
+++ b/src/types/tuple.rs
@@ -57,18 +57,24 @@ impl PyTuple {
         self.len() == 0
     }
 
-    /// Takes a slice of the tuple pointed from `low` to `high` and returns it as a new tuple.
-    pub fn slice(&self, low: isize, high: isize) -> &PyTuple {
+    /// Takes the slice `self[low:high]` and returns it as a new tuple.
+    ///
+    /// Out-of-range indices are clipped to `self.len()`.
+    pub fn slice(&self, low: usize, high: usize) -> &PyTuple {
         unsafe {
-            self.py()
-                .from_owned_ptr(ffi::PyTuple_GetSlice(self.as_ptr(), low, high))
+            self.py().from_owned_ptr(ffi::PyTuple_GetSlice(
+                self.as_ptr(),
+                low as Py_ssize_t,
+                high as Py_ssize_t,
+            ))
         }
     }
 
     /// Takes a slice of the tuple from `low` to the end and returns it as a new tuple.
-    pub fn split_from(&self, low: isize) -> &PyTuple {
+    pub fn split_from(&self, low: usize) -> &PyTuple {
         unsafe {
-            let ptr = ffi::PyTuple_GetSlice(self.as_ptr(), low, self.len() as Py_ssize_t);
+            let ptr =
+                ffi::PyTuple_GetSlice(self.as_ptr(), low as Py_ssize_t, self.len() as Py_ssize_t);
             self.py().from_owned_ptr(ptr)
         }
     }
@@ -346,6 +352,17 @@ mod tests {
         });
     }
 
+    #[test]
+    fn test_slice() {
+        Python::with_gil(|py| {
+            let tup = PyTuple::new(py, &[2, 3, 5, 7]);
+            let slice = tup.slice(1, 3);
+            assert_eq!(2, slice.len());
+            let slice = tup.slice(1, 7);
+            assert_eq!(3, slice.len());
+        });
+    }
+
     #[test]
     fn test_iter() {
         Python::with_gil(|py| {