diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 9db5cf769fd..22474ba93b8 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -244,6 +244,13 @@ jobs:
           manylinux: auto
           args: --release -i python3.9 --no-sdist -m examples/maturin-starter/Cargo.toml
 
+      - name: Test cross compilation
+        if: ${{ matrix.platform.os == 'macos-latest' && matrix.python-version == '3.9' }}
+        uses: messense/maturin-action@v1
+        with:
+          target: aarch64-apple-darwin
+          args: --release -i python3.9 --no-sdist -m examples/maturin-starter/Cargo.toml
+
     env:
       CARGO_TERM_VERBOSE: true
       CARGO_BUILD_TARGET: ${{ matrix.platform.rust-target }}
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6ec1b007fbc..6cedcf55c91 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Fixed
 
 - Fix incorrect platform detection for Windows in `pyo3-build-config`. [#2198](https://github.com/PyO3/pyo3/pull/2198)
+- Fix cross compiling to aarch64 macOS. [#2201](https://github.com/PyO3/pyo3/pull/2201)
 
 ## [0.16.0] - 2022-02-27
 
diff --git a/pyo3-build-config/src/impl_.rs b/pyo3-build-config/src/impl_.rs
index debbdff533c..25b6db174bd 100644
--- a/pyo3-build-config/src/impl_.rs
+++ b/pyo3-build-config/src/impl_.rs
@@ -623,7 +623,16 @@ pub fn cross_compiling(
     let cross_lib_dir = env_var("PYO3_CROSS_LIB_DIR");
     let cross_python_version = env_var("PYO3_CROSS_PYTHON_VERSION");
 
-    let target_triple = format!("{}-{}-{}", target_arch, target_vendor, target_os);
+    let target_triple = format!(
+        "{}-{}-{}",
+        target_arch,
+        target_vendor,
+        if target_os == "macos" {
+            "darwin"
+        } else {
+            target_os
+        }
+    );
 
     if cross.is_none() && cross_lib_dir.is_none() && cross_python_version.is_none() {
         // No cross-compiling environment variables set; try to determine if this is a known case