diff --git a/CHANGELOG.md b/CHANGELOG.md
index db19eba9431..b239f3ed59e 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -14,6 +14,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Allow dependent crates to access config values from `pyo3-build-config` via cargo link dep env vars. [#2092](https://github.com/PyO3/pyo3/pull/2092)
 - Added methods on `InterpreterConfig` to run Python scripts using the configured executable. [#2092](https://github.com/PyO3/pyo3/pull/2092)
 - Added FFI definitions for `PyType_FromModuleAndSpec`, `PyType_GetModule`, `PyType_GetModuleState` and `PyModule_AddType`. [#2250](https://github.com/PyO3/pyo3/pull/2250)
+- Add `PyString::intern` to enable usage of the Python's built-in string interning. [#????](https://github.com/PyO3/pyo3/pull/????)
 
 ### Changed
 
diff --git a/src/types/string.rs b/src/types/string.rs
index 76610a108ae..1af4effe14e 100644
--- a/src/types/string.rs
+++ b/src/types/string.rs
@@ -8,6 +8,7 @@ use crate::{
     ToPyObject,
 };
 use std::borrow::Cow;
+use std::ffi::CStr;
 use std::os::raw::c_char;
 use std::str;
 
@@ -69,7 +70,6 @@ impl<'a> PyStringData<'a> {
     /// C APIs that skip input validation (like `PyUnicode_FromKindAndData`) and should
     /// never occur for strings that were created from Python code.
     pub fn to_string(self, py: Python<'_>) -> PyResult<Cow<'a, str>> {
-        use std::ffi::CStr;
         match self {
             Self::Ucs1(data) => match str::from_utf8(data) {
                 Ok(s) => Ok(Cow::Borrowed(s)),
@@ -144,6 +144,29 @@ impl PyString {
         unsafe { py.from_owned_ptr(ffi::PyUnicode_FromStringAndSize(ptr, len)) }
     }
 
+    /// Intern the given null-terminated string
+    ///
+    /// This will return a reference to the same Python string object if called repeatedly with the same string.
+    ///
+    /// Panics if out of memory.
+    ///
+    /// # Example
+    ///
+    /// ```
+    /// use std::ffi::CStr;
+    /// # use pyo3::{types::PyString, Python};
+    ///
+    /// # Python::with_gil(|py| {
+    /// let c_str = CStr::from_bytes_with_nul(b"foobar\0").unwrap();
+    /// let py_str = PyString::intern(py, c_str);
+    /// assert_eq!(c_str.to_str().unwrap(), py_str.to_str().unwrap());
+    /// # });
+    /// ```
+    pub fn intern<'p>(py: Python<'p>, s: &CStr) -> &'p PyString {
+        let ptr = s.as_ptr() as *const c_char;
+        unsafe { py.from_owned_ptr(ffi::PyUnicode_InternFromString(ptr)) }
+    }
+
     /// Attempts to create a Python string from a Python [bytes-like object].
     ///
     /// [bytes-like object]: (https://docs.python.org/3/glossary.html#term-bytes-like-object).
@@ -592,4 +615,19 @@ mod tests {
             assert_eq!(data.to_string_lossy(), Cow::Owned::<str>("𠀀�".into()));
         });
     }
+
+    #[test]
+    fn test_intern_string() {
+        Python::with_gil(|py| {
+            let s = CStr::from_bytes_with_nul(b"foobar\0").unwrap();
+
+            let py_string1 = PyString::intern(py, s);
+            assert_eq!(s.to_str().unwrap(), py_string1.to_str().unwrap());
+
+            let py_string2 = PyString::intern(py, s);
+            assert_eq!(s.to_str().unwrap(), py_string2.to_str().unwrap());
+
+            assert_eq!(py_string1.as_ptr(), py_string2.as_ptr());
+        });
+    }
 }