diff --git a/pkgs/development/python-modules/flask-restful/default.nix b/pkgs/development/python-modules/flask-restful/default.nix
index db7a63c5ed4a25..1af875d4bbc599 100644
--- a/pkgs/development/python-modules/flask-restful/default.nix
+++ b/pkgs/development/python-modules/flask-restful/default.nix
@@ -20,6 +20,10 @@ buildPythonPackage rec {
     sha256 = "0gm5dz088v3d2k1dkcp9b3nnqpkk0fp2jly870hijj2xhc5nbv6c";
   };
 
+  patches = [
+    ./werkzeug-2.1.0-compat.patch
+  ];
+
   propagatedBuildInputs = [
     aniso8601
     flask
diff --git a/pkgs/development/python-modules/flask-restful/werkzeug-2.1.0-compat.patch b/pkgs/development/python-modules/flask-restful/werkzeug-2.1.0-compat.patch
new file mode 100644
index 00000000000000..c8707b2394354d
--- /dev/null
+++ b/pkgs/development/python-modules/flask-restful/werkzeug-2.1.0-compat.patch
@@ -0,0 +1,114 @@
+Fixes compatibility with Werkzeug 2.1.0 ported over from flask-restx#423.
+
+https://github.com/python-restx/flask-restx/pull/423
+
+diff --git a/flask_restful/reqparse.py b/flask_restful/reqparse.py
+index 9bb3099..5c59594 100644
+--- a/flask_restful/reqparse.py
++++ b/flask_restful/reqparse.py
+@@ -114,7 +114,10 @@ class Argument(object):
+         :param request: The flask request object to parse arguments from
+         """
+         if isinstance(self.location, six.string_types):
+-            value = getattr(request, self.location, MultiDict())
++            if self.location in {"json", "get_json"}:
++                value = request.get_json(silent=True)
++            else:
++                value = getattr(request, self.location, MultiDict())
+             if callable(value):
+                 value = value()
+             if value is not None:
+@@ -122,7 +125,10 @@ class Argument(object):
+         else:
+             values = MultiDict()
+             for l in self.location:
+-                value = getattr(request, l, None)
++                if l in {"json", "get_json"}:
++                    value = request.get_json(silent=True)
++                else:
++                    value = getattr(request, l, None)
+                 if callable(value):
+                     value = value()
+                 if value is not None:
+diff --git a/tests/test_api.py b/tests/test_api.py
+index 15f12eb..9a9cceb 100644
+--- a/tests/test_api.py
++++ b/tests/test_api.py
+@@ -936,7 +936,7 @@ class APITestCase(unittest.TestCase):
+         app = app.test_client()
+         resp = app.get('/api')
+         self.assertEqual(resp.status_code, 302)
+-        self.assertEqual(resp.headers['Location'], 'http://localhost/')
++        self.assertEqual(resp.headers['Location'], '/')
+ 
+     def test_json_float_marshalled(self):
+         app = Flask(__name__)
+diff --git a/tests/test_reqparse.py b/tests/test_reqparse.py
+index 1d75e40..e5c586b 100644
+--- a/tests/test_reqparse.py
++++ b/tests/test_reqparse.py
+@@ -23,8 +23,9 @@ class ReqParseTestCase(unittest.TestCase):
+         with app.app_context():
+             parser = RequestParser()
+             parser.add_argument('foo', choices=('one', 'two'), help='Bad choice: {error_msg}')
+-            req = Mock(['values'])
++            req = Mock(["values", "get_json"])
+             req.values = MultiDict([('foo', 'three')])
++            req.get_json.return_value = None
+             parser.parse_args(req)
+             expected = {'foo': 'Bad choice: three is not a valid choice'}
+             abort.assert_called_with(400, message=expected)
+@@ -35,8 +36,9 @@ class ReqParseTestCase(unittest.TestCase):
+         with app.app_context():
+             parser = RequestParser()
+             parser.add_argument('foo', choices=('one', 'two'), help=u'Bad choice: {error_msg}')
+-            req = Mock(['values'])
++            req = Mock(["values", "get_json"])
+             req.values = MultiDict([('foo', u'\xf0\x9f\x8d\x95')])
++            req.get_json.return_value = None
+             parser.parse_args(req)
+             expected = {'foo': u'Bad choice: \xf0\x9f\x8d\x95 is not a valid choice'}
+             abort.assert_called_with(400, message=expected)
+@@ -47,8 +49,9 @@ class ReqParseTestCase(unittest.TestCase):
+         with app.app_context():
+             parser = RequestParser()
+             parser.add_argument('foo', choices=['one', 'two'], help='Please select a valid choice')
+-            req = Mock(['values'])
++            req = Mock(["values", "get_json"])
+             req.values = MultiDict([('foo', 'three')])
++            req.get_json.return_value = None
+             parser.parse_args(req)
+             expected = {'foo': 'Please select a valid choice'}
+             abort.assert_called_with(400, message=expected)
+@@ -58,8 +61,9 @@ class ReqParseTestCase(unittest.TestCase):
+         def bad_choice():
+             parser = RequestParser()
+             parser.add_argument('foo', choices=['one', 'two'])
+-            req = Mock(['values'])
++            req = Mock(["values", "get_json"])
+             req.values = MultiDict([('foo', 'three')])
++            req.get_json.return_value = None
+             parser.parse_args(req)
+             abort.assert_called_with(400, message='three is not a valid choice')
+         app = Flask(__name__)
+@@ -190,7 +194,8 @@ class ReqParseTestCase(unittest.TestCase):
+         self.assertTrue(len(arg.source(req)) == 0)  # yes, basically you don't find it
+ 
+     def test_source_default_location(self):
+-        req = Mock(['values'])
++        req = Mock(['values', 'get_json'])
++        req.get_json.return_value = None
+         req._get_child_mock = lambda **kwargs: MultiDict()
+         arg = Argument('foo')
+         self.assertEqual(arg.source(req), req.values)
+@@ -215,8 +220,9 @@ class ReqParseTestCase(unittest.TestCase):
+         args = parser.parse_args(req)
+         self.assertEqual(args['foo'], "bar")
+ 
+-        req = Mock()
++        req = Mock(['get_json'])
+         req.values = ()
++        req.get_json.return_value = None
+         req.json = None
+         req.view_args = {"foo": "bar"}
+         parser = RequestParser()