diff --git a/python/lib/dependabot/python/file_updater/pip_compile_file_updater.rb b/python/lib/dependabot/python/file_updater/pip_compile_file_updater.rb
index 6b5d5dab932..e02e9ec65e5 100644
--- a/python/lib/dependabot/python/file_updater/pip_compile_file_updater.rb
+++ b/python/lib/dependabot/python/file_updater/pip_compile_file_updater.rb
@@ -430,6 +430,9 @@ def pip_compile_options_from_compiled_file(requirements_file)
           options << "--no-header" unless requirements_file.content.include?("autogenerated by pip-c")
 
           options << "--pre" if requirements_file.content.include?("--pre")
+
+          options << "--strip-extras" if requirements_file.content.include?("--strip-extras")
+
           options
         end
 
diff --git a/python/spec/dependabot/python/file_updater/pip_compile_file_updater_spec.rb b/python/spec/dependabot/python/file_updater/pip_compile_file_updater_spec.rb
index 3bf187500ba..f65c16340df 100644
--- a/python/spec/dependabot/python/file_updater/pip_compile_file_updater_spec.rb
+++ b/python/spec/dependabot/python/file_updater/pip_compile_file_updater_spec.rb
@@ -505,5 +505,21 @@
         end
       end
     end
+
+    context "with stripped extras" do
+      let(:manifest_fixture_name) { "strip_extras.in" }
+      let(:generated_fixture_name) { "pip_compile_strip_extras.txt" }
+      let(:dependency_name) { "cachecontrol" }
+      let(:dependency_version) { "0.12.10" }
+      let(:dependency_previous_version) { "0.12.9" }
+
+      it "doesn't add an extras annotation on cachecontrol" do
+        expect(updated_files.count).to eq(1)
+        expect(updated_files.first.content).to include("--strip-extras")
+        expect(updated_files.first.content).to include("cachecontrol==0.12.10")
+        expect(updated_files.first.content).
+          to_not include("cachecontrol[filecache]==")
+      end
+    end
   end
 end
diff --git a/python/spec/fixtures/pip_compile_files/strip_extras.in b/python/spec/fixtures/pip_compile_files/strip_extras.in
new file mode 100644
index 00000000000..b1db984ed70
--- /dev/null
+++ b/python/spec/fixtures/pip_compile_files/strip_extras.in
@@ -0,0 +1 @@
+cachecontrol[filecache]
diff --git a/python/spec/fixtures/requirements/pip_compile_strip_extras.txt b/python/spec/fixtures/requirements/pip_compile_strip_extras.txt
new file mode 100644
index 00000000000..871e3b538b2
--- /dev/null
+++ b/python/spec/fixtures/requirements/pip_compile_strip_extras.txt
@@ -0,0 +1,22 @@
+#
+# This file is autogenerated by pip-compile with python 3.10
+# To update, run:
+#
+#    pip-compile --strip-extras --output-file=constraints.txt constraints.in
+#
+cachecontrol==0.12.10
+    # via -r constraints.in
+certifi==2021.10.8
+    # via requests
+charset-normalizer==2.0.7
+    # via requests
+idna==3.3
+    # via requests
+lockfile==0.12.2
+    # via cachecontrol
+msgpack==1.0.2
+    # via cachecontrol
+requests==2.26.0
+    # via cachecontrol
+urllib3==1.26.7
+    # via requests