diff --git a/src/lightning_app/components/serve/python_server.py b/src/lightning_app/components/serve/python_server.py
index f0361f9db5046..731bf1c37e969 100644
--- a/src/lightning_app/components/serve/python_server.py
+++ b/src/lightning_app/components/serve/python_server.py
@@ -3,6 +3,7 @@
 from pathlib import Path
 from typing import Any, Dict, Optional
 
+import torch
 import uvicorn
 from fastapi import FastAPI
 from pydantic import BaseModel
@@ -105,7 +106,7 @@ def predict(self, request):
         self._input_type = input_type
         self._output_type = output_type
 
-    def setup(self) -> None:
+    def setup(self, *args, **kwargs) -> None:
         """This method is called before the server starts. Override this if you need to download the model or
         initialize the weights, setting up pipelines etc.
 
@@ -154,7 +155,8 @@ def _attach_predict_fn(self, fastapi_app: FastAPI) -> None:
         output_type: type = self.configure_output_type()
 
         def predict_fn(request: input_type):  # type: ignore
-            return self.predict(request)
+            with torch.inference_mode():
+                return self.predict(request)
 
         fastapi_app.post("/predict", response_model=output_type)(predict_fn)
 
@@ -207,7 +209,7 @@ def run(self, *args: Any, **kwargs: Any) -> Any:
 
         Normally, you don't need to override this method.
         """
-        self.setup()
+        self.setup(*args, **kwargs)
 
         fastapi_app = FastAPI()
         self._attach_predict_fn(fastapi_app)